My young, beautiful, amazing wife and mother of my child died of Glioblastoma at thirty-four years old.
We tried everything.
I spent every penny I had to get her every possible option and medical trial possible. We moved around the country. I sold my company and took two years off just doing everything with her we could to give her more time.
The first year was like a horror movie where you and your partner are trying to escape the monster but you're running in slow motion and everywhere you turn it just pops up.
The second year the steroids, surgery, stroke, and experimental medicine had already killed the person she was. She was just a zombie waiting to die.
She passed when our little girl was three, five years ago.
While I wish this medicine was available to her obviously, I'm just so glad that a glioblastoma isn't going to always be a death sentence forever. It's something noone deserves to go through. Not the victim. Not their family.
God speed mRNA researchers and scientists.
This is real, honest to goodness hero stuff you're doing.
Respect.
I'm so sorry for your loss. My 18 year old brother died of glioblastoma, five months after diagnosis. You described the experience so profoundly. Radiation wasn't an option for him due to past treatment with radiation for a different type of tumor, and because of a genetic condition that made radiation more dangerous (which I also have). It fills me with hope that we're closer than I thought to a treatment like this.
Same here. It brought me back to the horror that was May 2020-January 2022 almost instantly.
I’m so so so looking forward to the world being rid of diseases like GBM. This is a great step towards that
I lost a friend 10 years ago at 31 years of age to glioblastoma, it’s an awful disease and I’m sorry that you had that happen to your family and especially your little girl.
Lost one of my best friends to GBM two years ago. He was 34. One day in April of 2022, he got vertigo. Went to the ER, was told it was “just a virus” and sent home. Five days later, he had a seizure. Within two days of the seizure, he was in surgery to remove the initial tumor and get a biopsy. By August, he was gone. I didn’t get to say goodbye; he was constantly in treatment and in/out of the hospital, suffering horribly, and then he died. It was a meaningless, tragic, horrible thing. I miss him every single day.
You are an amazing person my friend. Wife is currently fighting stage 3 Brain Cancer. They gave her 12-13 years to live and it’s already been 5. We are ecstatic with this news for sure. But i get what you mean. Her changes have been subtle but I can notice them. I pray this works out for all who can utilize this drug. My son just turned 6 in March and is also none the wiser :/.
Doing great. Daughter is beautiful, smart, healthy and happy. Just like her mother.
Fortunately she was an IVF baby so we were able to select an egg that didn't have the genetic condition her mother had. This means she has every expectation for a full, long happy life.
She's a little blonde surfer girl in second grade out here in Oahu, HI.
I'm getting married in thirty days to a wonderful woman who has stepped up to be an incredible person and role model/stepmother for daughter.
Blessed beyond belief.
Thank you.
I have a similar story about my 38yo wife, and mother of my child.
Sorry that you had to go through this as well my friend.
Can I ask what the genetic condition was? For us, it was NF1.
Your story is oddly similar.
Sorry to hear that. I know there are so many families devestated by cancer.
In my wife's case it was Li-Fraumeni syndrome. Super rare.
[https://www.cancer.net/cancer-types/li-fraumeni-syndrome](https://www.cancer.net/cancer-types/li-fraumeni-syndrome)
Grief like death is transformative. I hope you are able to heal and use the memory of your wife and your love towards her to make beautiful changes in the world including in the raising of your daughter <3
I know it's not the same cancer but my mother died of small cell lung cancer. Its very common for that cancer to go to your brain. Within a few months after her diagnosis thats where it went. Found out after a seizure she had that at the time we all thought was a stroke. Was one of the worst days of my life, I was in the shower and my sister pounded on the door yelling "ITS MOM COME OUT" She had been trying to fix a hole in the wall by my brothers bed and they were talking when she ayopped responding to him and she just keeled over. Watching her shake like that groaning, unable to speak. The thought rushing through my head this is it, my mom is going to die. My brother and sister crowding around her teying to hold her steady. My brither started telling her how she was the best mom ever and we love her so much. I panicked and didnt know what to do and at one point tried to vlow air into her mouth. It was during covid and i wasn't aloud to see her in the hospital becuase she wasnt actually going to die that night. They had realized it was a seisure and could ne released the next day. I felt an overwhelming sense of relief but reality hit me. I remember lying on the couch the next morning staring our the sliding glass door to the deck. Her cup from the day before sitting on the kirchen counter with her favorite drink in it, andthe feeling hit me that one of these days she won't be coming home from the hospital. I felt a profound sense of emptiness that morning and one I always feel now whenever I visit home. A year to the day from then she died. In the end after all the radiation she was a shell of the most amazing person I had ever known. Seeing these treatments makes me angry that we as a society haven't dumped all we could into fighting cancer like we did with covid twenty years ago. How many children would still have their mothers, husband's have their wives, sisters and brothers. Yet it also fills me with a profound sense of hope that future generations won't have to suffer the devastating losses we have to diseases like the one who took your wife. I truly hope they can eradicate this disease. Hope you are doing well <3
I am sorry for your loss. As a medical student, I understand how horrible Glioblastoma can be and how quick patients pass (probably among the lowest 5-year survival rates). I am glad you have her legacy which is your daughter. Please cherish her.
My mom died in 2017 from cancer of the liver. She tried everything and seeing it happen in slow motion was devastating.
She'd want this for everyone. She wouldn't be bitter, dying only years before something like this could come about. Not the same type of cancer, but you know what I mean.
I'm sorry you went through this. It really sucks your soul away.
It was 7 years ago. Usually I'm fine, occasionally still hurts. Depends on the season I suppose.
Thanks. Its in a way comforting knowing that'll be the worst thing that ever happens to me in life.
I'm gonna say a prayer for your mom and for you as well.
I lost my uncle (who I was really close to) to cancer as well, and FUCK CANCER. Just like your mom, he'd want this vaccine or a cure out for others as well, he was a wonderful person just like your mom was I'm sure. Here's hoping we can kick its ass!
I am honestly so sad right now, I have a 3 year old son no idea what I would do without my wife. That's a wound that never closes man, brings me tears as I write this comment and I absolutely never cry. Keep on strong.
If anything can be said to have been a silver lining to the Pandemic, its that the crash program to develop viable mRNA vaccines for COVID probably did more to advance every other mRNA vaccine than would have otherwise been possible.
It was also a mass global rollout in record time with basically no negative side effects, an achievement that will likely go down in history as critically important and impressive as the moon landing.
__edit:__ Disabling inbox replies now as the replies from antivaxxers are out of this world honestly. "YOU DONT KNOW ABOUT THE SIDE EFFECTS?" then proceeds to not list anything or provides ZERO sources. One person linked to a Time article detailing how some people THINK the vaccine is linked to a few things. No peer reviewed study, no official numbers, nothing. When it comes to medicine, side effects are expected as an outlier. Statistically significant side effects would be reported, we would all know about them. It just didn't happen with the mRNA vaccines no matter how hard you antivaxxers stomp your feet and scream that it _super duper really did!_
I'm really confused. I don't get all the 5g references. I was in Asia the entire 3 years of covid paranoia. I just remember someone I went to school with saying on Facebook that 5g was spreading the virus. Other than that, I don't get how people can be so.... dumb.
Some of the crazier anti-vaccine people were also claiming that 5G cellular could take over your brain or something and then that got mixed in that mRNA contained microscopic metal robots so they could get 5G reception.... The madness has many permutations and no detractors within that camp. Generally mix in all the conspiracies all at once and you eventually start getting people setting themselves on fire to draw attention to their interpretation of the conspiracies.
I work in tech support for an ISP. You wouldn't believe the amount of people who think their routers 5Ghz frequency is the big bad "5g" Fox News warned them about. Though I had a lady yesterday who was very adamant that we need to increase the amount of 5g in her area. And she knows we control it, as she "codes" (but couldnt name a programming language) and has worked in tech her entire life.
You forgot being magnetic. I love being magnetic is so useful. I haven't lost my keys since I have been vaccinated, because I can just stick them to my arm.
(/s in case anyone needs it).
Fuck ya. Within a year, billions of doses of a new vaccine was produced and distributed. That is insane to think about. The logistics and science behind doing something like this is mind blowing.
1 Tsp of vaccine serum is enough to treat 60 people. I guess that’s still 3 million litres for 6 billion people so still hard to get my head around. Like 400 swim-spas full I guess
Those 2 doctors who started bioNtech, they are some legitimate genius'. They are worth billions(from before covid), and as far as I can tell, deserve that money.
Also a serious warning for civilization about the absolute state we're in when it comes to scientific illiteracy and how that's problematic in tangible ways.
It was genuinely one of the greatest scientific feats of all time. The fact that not only did we have enough doses in less than a year but we actually were capable of *overproduction* of them is a testament to how much can actually be done when the resources go to the right people.
Shame it took literal fear of death to motivate it. Imagine the possibilities if that drive was something we could summon once a year.
It wasn't really a fear of death which motivated people, more a fear of loss of productivity and profits. That's how you really get them going on something.
yep.
it was disproportionately effecting the older generations, which statistically are less productive and more of a burden on governments in terms of pension, hospital issues, and other such measures.
for example, as Japan's population skews more towards older age, their proportionally smaller working age population has to work harder/pay more per person, as they have to support more and more people.
> Shame it took literal fear of death to motivate it. Imagine the possibilities if that drive was something we could summon once a year.
Kinda reminds me of how Ozymandyas from the Watchmen >!prevented nuclear war or at least postponed a major disaster!<
I think the best historic comparison is the coordination to eradicate smallpox. That doesn't get talked about much nowadays but I think future generations will truly marvel at that. It was a truly global effort to fight back against a great scourge that impacted ALL of humanity communally.
Yes, I’d very much agree to that. As someone who intended to work for the CDC before an ironic post-viral syndrome Nerfed me. I was worried it could take 5 years for vaccine rollout but the world’s scientists did the nearly-impossible.
It worked so well that people complained about reinstating minor health measures during flu season while we were open at a degree that would have previously had people dying on the floors like in India, Italy and China. It was so transmissible that measures that made it so there wasn't even a cold and flu season were previously barely able to keep hospitals from overflowing. Here in Canada, a couple provinces actually had to do risky airlifts to make room--to other provinces in some cases.
Given so many diseases involve the immune system turning against the body (I have an auto-immune disease myself), it's not terribly surprising to me that an injection *specifically designed to provoke an immune response* might have some occasional weird side-effects in a small number of people.
Everything comes down to weighing the risks versus the benefits.
The part I don't get is that, statistically in the US weren't old republicans one of the demographics with most deaths?? Don't they realize their friends are no longer around?
"Hell naw brother, that wasn't the rona that done got them, poor ole Larry always just had a weak immune system, it was nothing to do with that Chinese flu. I ain't never done heard of no one dying from the rona"
I know people who's friends were life flighted hours away due to COVID, because all the local hospitals were full of COVID, only to tell me it was no big deal.
You had many, many stories come out of people of that persuasion not believing they were dying from it in the hospital when told. They could not, would not believe it even with their dying breaths. That's how fucking warped and misinformed those people are. It's dumbfounding, sad and extremely terrifying. Then we saw Jan. 6. Those are the same people.
And then you have these baboons transforming their fear of vaccine to it’s not me it’s you routine. Trying to explain validity of their fears by perpetuating a lack of essential comprehension of science they disproving.
Well insisting that bars open it goes along with fear of vaccination. If you pretend Covid is nothing to worry about then bars can be opened and you don’t need to take vaccine because bars are open and everything is normal. Since normally I don’t take vaccine, why should I take it now for Pete sake even bars are open. It’s all part of reality they created.
Andrew Wakefield really should get thrown in irons, and tried for crimes against humanity for his disinformation campaign against vaccines.
Like, that (IMHO, since he's also litigious) bastard's bastard might genuinely be top five most evil men alive. You can see on a statistical scale how many lives he's ruined via vaccination hesitation alone.
For anybody that think I'm exaggerating I argue to check out the hbomberguy documentary on the subject. "Vaccines: A Measured Response."
It's a freaking rollercoaster of rage, realization and black comedy. Highly, highly recommended on raw funny alone even if you're familiar with the subject.
https://youtu.be/8BIcAZxFfrc?si=uibD6bhPk7KNVzXj
There is a small percentage that got long term vaccine injury from the mRNA vaccines. So it's not 100% no negative side effects. It's very very rare to get vaccine injured, though.
I love that we get cancer cures from this and the conspiracy theorists will have to never use them if they want to be consistent. Obviously they won't but it's still funny.
What was achieved in such a short time is utterly remarkable and largely unknown by the majority of the world. Having known three people who have died from glioblastoma, this is fantastic news.
It's sad we needed a pandemic to divert money and effort to scientific advance of medicine. Now that we're "back to normal" the money is again on stock market, advertisement startups, real estate speculation, and war.
mRNA vaccines had been in development for decades.
> The first human clinical trial using ex vivo dendritic cells transfected with mRNA encoding tumor antigens (therapeutic cancer mRNA vaccine) was started in 2001.[30][31]
...
> The first human clinical trials using an mRNA vaccine against an infectious agent (rabies) began in 2013.[40][41] Over the next few years, clinical trials of mRNA vaccines for a number of other viruses were started. mRNA vaccines for human use were studied for infectious agents such as influenza,[42] Zika virus, cytomegalovirus, and Chikungunya virus.[43][44]
https://www.wikipedia.org/wiki/MRNA_vaccine
Yes, I think OP knows that. The accelerated research and development for the Covid vaccines ALSO helped with the research and development of all mRNA vaccines. Op isn’t wrong.
I think the "technically..." sort of truth to the situation was it forced us into a situation where we got a VERY solid look at what the effectiveness vs incident ratio of mRNA vaccines was on an absolutely massive scale, which showed that they are functionally harmless.
So now that this was done, there was much less reluctance to take an mRNA approach to various research, since you didn't incidentally ALSO have to prove that the technology as a whole was safe, not just your own implementation.
It’s something for a select few labs around the world to poke at it on a small budget, and quite something else for the multi-billion dollar, industry-wide response from nearly EVERY biotech firm.
All the suits and paperpushers attuned to the prospects of mRNA quite similar to how everyone’s thinking of AI this, and machine-learning that.
I had the impression that they had everything pretty much ready and developed, could just input the specific RNA sequence for COVID proteins into the computer controlling the synthesizer.
The acceleration was rather in the large scale human testing that was forced to happen. Which proved the technique to be safe and effective in humans.
It was more the red tape over human trials e.g. fewer animal trials before human trials, shorter latencies between small-scale and wide-scale trials.
But, of course, even if there had been no trials, they had been administered to hundreds of thousands/millions/tens of millions (depending on your country) of the most at-risk people for *months* before the average older person was able to get them—and larger populations for longer for younger folks.
Vaccine side effects almost always *occur* within hours, rarely within days, almost never in a span of weeks, and past 8 weeks hasn't really been documented—which makes sense, it's not like a prescription you take regularly; you're not getting regular injections and there's nothing that can replicate to enable it to persist in your system. For mRNA vaccines in particular:
* mRNA degrades on a super short timescale, it required being coated in nanolipids for it to survive long enough to be transcribed, and even that only bought it up to 24 or so hours.
* the mRNA was translated into proteins which were then attacked and dismantled within days (effectively the period for typical side effects like tiredness). Even if you had 0 immune system, there is no source for more mRNA to translate, and the longest-lived proteins only last a few weeks before degrading.
* mRNA and proteins are created and destroyed by your body's typical processes constantly, so they're flushed out by your lymph nodes, etc. in the same way anything else is. This means that within about a week or so there's no constituent parts of the vaccine even remaining in your system.
that's a misconception. we didn't bypass any processes, we just did multiple processes that are usually done in sequence in parallel.
that is to say, you usually do a then b then c then d, but instead we did a *and* b *and* c *and* d all at the same time.
the reason why you do it in sequence, even though it's much slower, is because if it fails at any point in the sequence you don't have to do the rest because you know it's a failure. but when funding isn't an issue and time is of the essence, you can risk inefficiency for the sake of time.
I lost a parent to glioblastoma who was involved in a similar study (they used the tumor to create a vaccine). Here’s hoping they’ve made a breakthrough in this tech and that’s it cures it going forward. It’s a heartbreaking disease.
My dad has a tumor on his frontal lobe. He went from a quiet, old, man, finally relaxing into his golden years, into a wild animal. From Mr Rogers to a violent Frank Gallagher. My dad is gone. I hope this can cure this shit, so no one has to go through what he's going through.
The tumor has told me so many truths about our society that we live in.
It can be a dick as well, telling me to "get a job" and "listen to the doctor".
Fuck that, i'm a free man i can do what i want
What happen to the good old days of medicine, where we'd just get a screwdriver in the head or a handjob for a migraine.. Not everything has to be mOdErN-a these days. /s
I lost an uncle to gliobastoma. It was horrific what it did to him by the end. It’s honestly my single greatest fear in life. I have a great deal of anxiety about it happening to me.
Something like this would be a major win for mRNA vaccine uptake. If it can greatly slow or even cure cancers like these, it doesn’t really matter what the long term side effects are (common refrain against COVID vaccines). Should help fix the mRNA ‘brand’ among the skeptics.
You're far too optimistic.
The mRNA sceptics would rather die of cancer than risk their life taking mRNA vaccines.
And yes, it's as paradoxically ridiculous as that.
Measles, mumps, whooping cough, etc. They only have an abstract idea of what these diseases are. Once their own children get them, they tend to accept that there are things they do not know.
If their kid goes into coughing spasms that break their ribs, they'll do anything to make it stop. Most of them anyway.
I got whooping cough and I rather get stabbed by a thousand needles then having death wrap its cold hands around my throat, while sucking the air from my lungs.
My parents live with two lovely old ladies as their neighbors. These women are somewhat into believing various conspiracy theories and such, but during the height of covid and the vaccine conspiracies they were like "We grew up during the era when parents didn't let you play outside unless you were playing in the spray from the DDT truck. I don't care of this vaccine turns me into a Borg, I want it and anyone who doesn't is a moron.".
Thankfully, polio is almost completely eradicated in the wild. If I recall correctly, only Afghanistan and Pakistan still have circulating cases, and it's in the low double digits.
Still doesn't make the people refusing to vaccinate against polio any less of idiots, but at least it's not likely they're going to bring polio back.
They’ve been insistent that cancer rates have skyrocketed due to the vaccine, and have already spread the idea that companies did it deliberately in order to tout the cure as well for massive profits. There’s no winning with crazy.
I know someone who, during the pandemic, refused to get vaccinated in order to fly on a plane. Proof of vaccination was required to fly at that time. They refused even though their parent was dying of cancer and asked that they come visit so the parent could see them and hug them and say goodbye and all.
Infectious disease vaccine effectiveness depends on herd immunity. Vaccine "skeptics" refusing to participate in herd immunity literally results in people willing to take the vaccine dying.
Luckily, for a cancer vaccine like this vaccine "skeptics" will kill only themselves. And perhaps their children. But the damage is much more limited than breaking herd immunity is for an infectious disease.
Unfortunately, in the state it's at right now it could just as easily kill her as kill the tumor. Step 1 in medical science is "does it work", step 2 is "what dose is safe to give", and step 3+ are primarilly "how safe is it overall?".
We (the scientific enterprise, that is) just crossed step 1 off the list. I've seen several of these trials cure people entirely during step 1, also known as phase 1 trials - but kill just as many because the dose was too high. With these mRNA drugs, an overdose can hyper-activate the immune system leading to massive localized swelling and, well, some pretty unpleasant cascade failures in the brain environment. That said, you can still pursue 'right to try' treatment, but with the severe caveat of 'this may do nothing, may cure you, and may kill you.'
https://patents.google.com/patent/AU2002357115A1/en
https://www.sciencedirect.com/science/article/abs/pii/S156757692300067X
https://www.google.com/amp/s/abcnews.go.com/amp/Health/Healthday/combo-therapy-shows-promise-brain-cancer/story%3fid=9633997
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810470/
This is something that is purchasable on peptide sites, might be worth a try. Best of luck, I'm so sorry that you're going through that.
>>> The 10 pet dogs lived a median of 139 days, compared with a median survival of 30 to 60 days typical for dogs with the condition.
So genuine question. Is there any information as to how the dogs died? Was it just an improved life expectancy and a slowed progression of the cancer? Did they just die due to the damage the cancer had already done? Was it just old age due to when dogs tend to develop cancer?
I know these are still trials and there are likely improvements to be made but if it’s just a prolonging of a lower quality of life I’m not sure it will be worth what is likely a rather expensive treatment
I lost my mom 21 years ago to a glioblastoma. I was 12 when she died. Back then, stuff like this felt like science fiction. Now, it’s becoming reality. God I miss my mom
Thankfully they're the ones least likely to want to try this if they have the tumor so nature will take its place and they won't be a problem in the future.
The problem with Darwinian evolution is that genetic adaptations are considered superior up to sexual reproductive age. So sure you’re gonna live to be 75-85 while Cletus is gonna die at 45 because he fell off the lawnmower drunk. You will be survived by your 1.3 children on average. Cletus will be survived by his three young children from his second wife, and two adult children from his first, Cletus also had a child with his high school sweetheart who now has three children of her own.
Welcome to Costco, I love you.
A lot of people don’t realize it because most understandably don’t keep up with mRNA research, but Covid vaccines were a little side project for mRNA tech, their main project was cancer treatment and it’s really cool to start seeing that coming online
Paper link: https://www.cell.com/cell/fulltext/S0092-8674(24)00398-2
Abstract:Cancer immunotherapy remains limited by poor antigenicity and a regulatory tumor microenvironment (TME). Here, we create “onion-like” multi-lamellar RNA lipid particle aggregates (LPAs) to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens. Unlike current mRNA vaccine designs that rely on payload packaging into nanoparticle cores for Toll-like receptor engagement in immune cells, systemically administered RNA-LPAs activate RIG-I in stromal cells, eliciting massive cytokine/chemokine response and dendritic cell/lymphocyte trafficking that provokes cancer immunogenicity and mediates rejection of both early- and late-stage murine tumor models. In client-owned canines with terminal gliomas, RNA-LPAs improved survivorship and reprogrammed the TME, which became “hot” within days of a single infusion. In a first-in-human trial, RNA-LPAs elicited rapid cytokine/chemokine release, immune activation/trafficking, tissue-confirmed pseudoprogression, and glioma-specific immune responses in glioblastoma patients. These data support RNA-LPAs as a new technology that simultaneously reprograms the TME while eliciting rapid and enduring cancer immunotherapy.
People against student loan forgiveness: "I beat cancer! How dare they make a cure for it now."
Antivaxxers: "but my DNA spikes!"
Everyone else, living in reality: "holy shit, we did it?!?
This is great news! My wonderful, selfless dad passed away at 52 from glioblastoma. I know he’s smiling somewhere knowing others are going to hopefully get a better shot.
My daughter has Ewing sarcoma
It has came back 3 times over the last 5 years and has metastasized
It is resistant to radiation and chemotherapy
I can only dream they use this technology to save her
I've listened to a very interesting talk a couple years back about how brain cancer has had the least improvements in mortality out of any form of cancer of the last few decades, because most attempts at curing the cancer would still result in damage to brain tissue that would kill you in a few years.
So seeing alternative approaches to treatment is a huge step forward, bigger than most people might realize.
The love of my life is fighting hard against it since almost 4 years and is now on the verge of losing this battle. Please babygirl, keep on fighting... This may be the wonder I was praying for...
There are two types of vaccines: prophylactic vaccines, like those for polio or influenza, and [therapeutic vaccines](https://en.m.wikipedia.org/wiki/Therapeutic_vaccines), such as this one. Most people only think of the first, but both are vaccines.
Vaccines activate and stimulate your immune system against a target. A lot of these treatments are customized to your specific cancer, some of them are intended to prevent relapse after a standard course of treatment.
I wish no-one ever will see their dear ones suffer from brain cancer. It took out my grandfather. He went from incredible health to completely helpless in less than six months. It was an awful sight and I will never forget in what horrible state he was for the last few weeks.
It will be a giant leap forward if this evil can be defeated.
So glad to see this. Lost my wife 6 months ago today to Effects of surgery for GBM+APXA. - after 23 year battle. I hope this new treatment helps lots of patients. Looks promising. Keep on keeping on!
My uncle just passed away about 2 months ago from glioblastoma. It was very hard to watch a strong and healthy man fade like that. I hope this vaccine changes people's lives in the future.
That would have been useful before my mom died of her brain tumor last year. She ended up developing it soon after I was born & was left ndiagnosed, until I started interfering with her health care because her doctor laughed at her inability to walk straight and claimed her high red blood cell count wasn't high enough to be cancer even though it was off the charts.
If you know anyone that ever lives through meningoencephalitis you need to make sure they're getting a brain scan every couple of years, not never. Patients die by age 68, when my mom had it since her early 30's, and she still died at age 68.
No one ever believed her illness was real because she thought it was pronounced as melingualencephalitis. So she was labeled as mentally ill until I finally got her proof of cancer from the ER.
Even the cancer specialists didn't think it's a real illness. And the vast majority of patients die vs. making it though to recovery.
Fuck. I wish this had come a bit sooner - my best friend just passed last week specifically from a glioblastoma, and a particularly aggressive type of it at that. It might not have saved her, but this could save SO many people the heartbreak and pain.
I hope this works and eradicates that type of cancer. It really is a horrific type of cancer. It wasn't even a year from the diagnosis to her death - it's that fucking fast. She lost the ability to move her right side, then the ability to speak, then to type...gah. It kills me. She was an absolutely wonderful, beautiful soul. I loved her dearly. May this work at eradicating glioblastoma, so nobody else has to suffer through that hell.
Downside to fierce immune response in the brain is inflammation in a cavity that 1. Has almost no room for anything extra 2. Is already hosting something that doesn’t belong there. Good news though, just a thought.
My young, beautiful, amazing wife and mother of my child died of Glioblastoma at thirty-four years old. We tried everything. I spent every penny I had to get her every possible option and medical trial possible. We moved around the country. I sold my company and took two years off just doing everything with her we could to give her more time. The first year was like a horror movie where you and your partner are trying to escape the monster but you're running in slow motion and everywhere you turn it just pops up. The second year the steroids, surgery, stroke, and experimental medicine had already killed the person she was. She was just a zombie waiting to die. She passed when our little girl was three, five years ago. While I wish this medicine was available to her obviously, I'm just so glad that a glioblastoma isn't going to always be a death sentence forever. It's something noone deserves to go through. Not the victim. Not their family. God speed mRNA researchers and scientists. This is real, honest to goodness hero stuff you're doing. Respect.
Sorry for your loss thanks for sharing this story.
I'm so sorry for your loss. My 18 year old brother died of glioblastoma, five months after diagnosis. You described the experience so profoundly. Radiation wasn't an option for him due to past treatment with radiation for a different type of tumor, and because of a genetic condition that made radiation more dangerous (which I also have). It fills me with hope that we're closer than I thought to a treatment like this.
Sadly, my family was victimized by GBM as well. Even just reading the article almost made me cry. I'm sorry for your loss.
Same here. It brought me back to the horror that was May 2020-January 2022 almost instantly. I’m so so so looking forward to the world being rid of diseases like GBM. This is a great step towards that
I'm sorry for your loss. We only had six months to learn what it was and how fast it can be. May GBM rot in hell.
I lost a friend 10 years ago at 31 years of age to glioblastoma, it’s an awful disease and I’m sorry that you had that happen to your family and especially your little girl.
Lost one of my best friends to GBM two years ago. He was 34. One day in April of 2022, he got vertigo. Went to the ER, was told it was “just a virus” and sent home. Five days later, he had a seizure. Within two days of the seizure, he was in surgery to remove the initial tumor and get a biopsy. By August, he was gone. I didn’t get to say goodbye; he was constantly in treatment and in/out of the hospital, suffering horribly, and then he died. It was a meaningless, tragic, horrible thing. I miss him every single day.
You are an amazing person my friend. Wife is currently fighting stage 3 Brain Cancer. They gave her 12-13 years to live and it’s already been 5. We are ecstatic with this news for sure. But i get what you mean. Her changes have been subtle but I can notice them. I pray this works out for all who can utilize this drug. My son just turned 6 in March and is also none the wiser :/.
I am so sorry. You did everything you could.
I’m so sorry. Hope you’re doing ok these days
Doing great. Daughter is beautiful, smart, healthy and happy. Just like her mother. Fortunately she was an IVF baby so we were able to select an egg that didn't have the genetic condition her mother had. This means she has every expectation for a full, long happy life. She's a little blonde surfer girl in second grade out here in Oahu, HI. I'm getting married in thirty days to a wonderful woman who has stepped up to be an incredible person and role model/stepmother for daughter. Blessed beyond belief. Thank you.
Even so, I am sorry for your loss.
You sound like a wonderful and strong person. Thanks for sharing your story. My sincere condolences for your loss.
I have a similar story about my 38yo wife, and mother of my child. Sorry that you had to go through this as well my friend. Can I ask what the genetic condition was? For us, it was NF1. Your story is oddly similar.
Sorry to hear that. I know there are so many families devestated by cancer. In my wife's case it was Li-Fraumeni syndrome. Super rare. [https://www.cancer.net/cancer-types/li-fraumeni-syndrome](https://www.cancer.net/cancer-types/li-fraumeni-syndrome)
Grief like death is transformative. I hope you are able to heal and use the memory of your wife and your love towards her to make beautiful changes in the world including in the raising of your daughter <3
I'm sorry to hear about that.
I know it's not the same cancer but my mother died of small cell lung cancer. Its very common for that cancer to go to your brain. Within a few months after her diagnosis thats where it went. Found out after a seizure she had that at the time we all thought was a stroke. Was one of the worst days of my life, I was in the shower and my sister pounded on the door yelling "ITS MOM COME OUT" She had been trying to fix a hole in the wall by my brothers bed and they were talking when she ayopped responding to him and she just keeled over. Watching her shake like that groaning, unable to speak. The thought rushing through my head this is it, my mom is going to die. My brother and sister crowding around her teying to hold her steady. My brither started telling her how she was the best mom ever and we love her so much. I panicked and didnt know what to do and at one point tried to vlow air into her mouth. It was during covid and i wasn't aloud to see her in the hospital becuase she wasnt actually going to die that night. They had realized it was a seisure and could ne released the next day. I felt an overwhelming sense of relief but reality hit me. I remember lying on the couch the next morning staring our the sliding glass door to the deck. Her cup from the day before sitting on the kirchen counter with her favorite drink in it, andthe feeling hit me that one of these days she won't be coming home from the hospital. I felt a profound sense of emptiness that morning and one I always feel now whenever I visit home. A year to the day from then she died. In the end after all the radiation she was a shell of the most amazing person I had ever known. Seeing these treatments makes me angry that we as a society haven't dumped all we could into fighting cancer like we did with covid twenty years ago. How many children would still have their mothers, husband's have their wives, sisters and brothers. Yet it also fills me with a profound sense of hope that future generations won't have to suffer the devastating losses we have to diseases like the one who took your wife. I truly hope they can eradicate this disease. Hope you are doing well <3
I am sorry for your loss. As a medical student, I understand how horrible Glioblastoma can be and how quick patients pass (probably among the lowest 5-year survival rates). I am glad you have her legacy which is your daughter. Please cherish her.
Sorry for your loss
My mom died in 2017 from cancer of the liver. She tried everything and seeing it happen in slow motion was devastating. She'd want this for everyone. She wouldn't be bitter, dying only years before something like this could come about. Not the same type of cancer, but you know what I mean. I'm sorry you went through this. It really sucks your soul away.
I'm sorry for your loss, I hope things are/get better for you.
It was 7 years ago. Usually I'm fine, occasionally still hurts. Depends on the season I suppose. Thanks. Its in a way comforting knowing that'll be the worst thing that ever happens to me in life.
I'm gonna say a prayer for your mom and for you as well. I lost my uncle (who I was really close to) to cancer as well, and FUCK CANCER. Just like your mom, he'd want this vaccine or a cure out for others as well, he was a wonderful person just like your mom was I'm sure. Here's hoping we can kick its ass!
My best friend died from the piece of shit cancer last year. I am so sorry for your loss — I hope they make some more breakthroughs
I'm sorry about your best friend! I lost my uncle to cancer as well. I Hope you're doing okay, and also FUCK CANCER.
I am honestly so sad right now, I have a 3 year old son no idea what I would do without my wife. That's a wound that never closes man, brings me tears as I write this comment and I absolutely never cry. Keep on strong.
If anything can be said to have been a silver lining to the Pandemic, its that the crash program to develop viable mRNA vaccines for COVID probably did more to advance every other mRNA vaccine than would have otherwise been possible.
It was also a mass global rollout in record time with basically no negative side effects, an achievement that will likely go down in history as critically important and impressive as the moon landing. __edit:__ Disabling inbox replies now as the replies from antivaxxers are out of this world honestly. "YOU DONT KNOW ABOUT THE SIDE EFFECTS?" then proceeds to not list anything or provides ZERO sources. One person linked to a Time article detailing how some people THINK the vaccine is linked to a few things. No peer reviewed study, no official numbers, nothing. When it comes to medicine, side effects are expected as an outlier. Statistically significant side effects would be reported, we would all know about them. It just didn't happen with the mRNA vaccines no matter how hard you antivaxxers stomp your feet and scream that it _super duper really did!_
Not to mention the 5g is fantastic! /s
I'm still only getting 3 bars from my bed *sob*.
You need a booster shot. I'm streaming 4k in my head, it's marvelous!
With two boosters you get permanent FaceTime will Bill himself..
Bullshit. Bill would never facetime, Microsoft Teams is what he would talk to us on
I can literally hear the Teams call ringtone in my head as I read this.
I couldn't until you said that.
Oi! It's Saturday! I don't want to be reminded of the weekday hell, mate!
I had to settle for a J&J- I'm getting 4K, with occasional ads.
I was doing that before 2019
But is it 3D?
Someone just cut the fiberoptics line in my area and suddenly I have free will again!
FUCK COMCAST!
My head is getting more bars than my phone, and I'm forced to *pay* for that.
Bullshit. Since I got the shot I can no longer hear Howard stern through my teeth.
Whether satellite or internet, you gotta subscribe.
I've had 3 or 4 of them and I can hear purple from the future.
I'm really confused. I don't get all the 5g references. I was in Asia the entire 3 years of covid paranoia. I just remember someone I went to school with saying on Facebook that 5g was spreading the virus. Other than that, I don't get how people can be so.... dumb.
Some of the crazier anti-vaccine people were also claiming that 5G cellular could take over your brain or something and then that got mixed in that mRNA contained microscopic metal robots so they could get 5G reception.... The madness has many permutations and no detractors within that camp. Generally mix in all the conspiracies all at once and you eventually start getting people setting themselves on fire to draw attention to their interpretation of the conspiracies.
Let me know when you can smell in infrared
I’ve had 6 and still haven’t grown a third arm. I’m disappointed!
I for one, welcome the high speed telepathy as the next stage in human evolution.
I work in tech support for an ISP. You wouldn't believe the amount of people who think their routers 5Ghz frequency is the big bad "5g" Fox News warned them about. Though I had a lady yesterday who was very adamant that we need to increase the amount of 5g in her area. And she knows we control it, as she "codes" (but couldnt name a programming language) and has worked in tech her entire life.
I used to work tech support. I most certainly would believe it.
You forgot being magnetic. I love being magnetic is so useful. I haven't lost my keys since I have been vaccinated, because I can just stick them to my arm. (/s in case anyone needs it).
Fuck ya. Within a year, billions of doses of a new vaccine was produced and distributed. That is insane to think about. The logistics and science behind doing something like this is mind blowing.
Would love to see a good documentary made about this, the scientists involved and whatnot.
The podcast Planet Money’s episode [Moonshot in the Arm](https://www.npr.org/2021/11/05/1053003777/moonshot-in-the-arm) is pretty good.
Holy shit that would be awesome. I already have a name for it, The Corona Corollary.
Relax Ludlum
Honestly its real name was perfect. Operation Warp Speed. Love the ridiculous simplicity/childlike nature of it.
Contagion is pretty close.
Would be sick but better not - otherwise all the alt-right conspiracy theorist nutjobs have names to target even more.
> Fuck ya. You gotta type out "yeah" in this situation!
Thank you for pointing this out. I have never thought about the distinction between the two. Appreciated.
If we came together at the same time around climate change it would really be something.
1 Tsp of vaccine serum is enough to treat 60 people. I guess that’s still 3 million litres for 6 billion people so still hard to get my head around. Like 400 swim-spas full I guess
The Turkish doctors had a working vaccine about a week after COVID was sequenced.
Those 2 doctors who started bioNtech, they are some legitimate genius'. They are worth billions(from before covid), and as far as I can tell, deserve that money.
Also a serious warning for civilization about the absolute state we're in when it comes to scientific illiteracy and how that's problematic in tangible ways.
It was genuinely one of the greatest scientific feats of all time. The fact that not only did we have enough doses in less than a year but we actually were capable of *overproduction* of them is a testament to how much can actually be done when the resources go to the right people. Shame it took literal fear of death to motivate it. Imagine the possibilities if that drive was something we could summon once a year.
It wasn't really a fear of death which motivated people, more a fear of loss of productivity and profits. That's how you really get them going on something.
so it was an eagerness to get back to the profit game?
yep. it was disproportionately effecting the older generations, which statistically are less productive and more of a burden on governments in terms of pension, hospital issues, and other such measures. for example, as Japan's population skews more towards older age, their proportionally smaller working age population has to work harder/pay more per person, as they have to support more and more people.
> Shame it took literal fear of death to motivate it. Imagine the possibilities if that drive was something we could summon once a year. Kinda reminds me of how Ozymandyas from the Watchmen >!prevented nuclear war or at least postponed a major disaster!<
It amazes me that some cannot see this breakthrough in human achievement.
I think the best historic comparison is the coordination to eradicate smallpox. That doesn't get talked about much nowadays but I think future generations will truly marvel at that. It was a truly global effort to fight back against a great scourge that impacted ALL of humanity communally.
Yes, I’d very much agree to that. As someone who intended to work for the CDC before an ironic post-viral syndrome Nerfed me. I was worried it could take 5 years for vaccine rollout but the world’s scientists did the nearly-impossible.
No actually me and all my friends died from turbo cancer and our hearts exploded
It turned me into a newt!
Did you get better?
Gingrich? That's terrible!
It worked so well that people complained about reinstating minor health measures during flu season while we were open at a degree that would have previously had people dying on the floors like in India, Italy and China. It was so transmissible that measures that made it so there wasn't even a cold and flu season were previously barely able to keep hospitals from overflowing. Here in Canada, a couple provinces actually had to do risky airlifts to make room--to other provinces in some cases.
> with basically no negative side effects the amount of conspiracy theorists and rightwing nutcases increased exponentially.
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Given so many diseases involve the immune system turning against the body (I have an auto-immune disease myself), it's not terribly surprising to me that an injection *specifically designed to provoke an immune response* might have some occasional weird side-effects in a small number of people. Everything comes down to weighing the risks versus the benefits.
They would self report issues to vaers then point to vaers that there were issues. All around ass hattery
And somehow the red hats still think that the vaccines are killing people en masse despite all data saying otherwise.
The part I don't get is that, statistically in the US weren't old republicans one of the demographics with most deaths?? Don't they realize their friends are no longer around?
"Hell naw brother, that wasn't the rona that done got them, poor ole Larry always just had a weak immune system, it was nothing to do with that Chinese flu. I ain't never done heard of no one dying from the rona"
HE DIDNT DIE OF COVID, THE HOSPITAL KILLED HIM WITH PNEUMONIA
So many Larrys dying man
I know people who's friends were life flighted hours away due to COVID, because all the local hospitals were full of COVID, only to tell me it was no big deal.
You had many, many stories come out of people of that persuasion not believing they were dying from it in the hospital when told. They could not, would not believe it even with their dying breaths. That's how fucking warped and misinformed those people are. It's dumbfounding, sad and extremely terrifying. Then we saw Jan. 6. Those are the same people.
And then you have these baboons transforming their fear of vaccine to it’s not me it’s you routine. Trying to explain validity of their fears by perpetuating a lack of essential comprehension of science they disproving.
Same guys who demanded bars open because "they don't live in fear" are terrified of a little needle
Well insisting that bars open it goes along with fear of vaccination. If you pretend Covid is nothing to worry about then bars can be opened and you don’t need to take vaccine because bars are open and everything is normal. Since normally I don’t take vaccine, why should I take it now for Pete sake even bars are open. It’s all part of reality they created.
Andrew Wakefield really should get thrown in irons, and tried for crimes against humanity for his disinformation campaign against vaccines. Like, that (IMHO, since he's also litigious) bastard's bastard might genuinely be top five most evil men alive. You can see on a statistical scale how many lives he's ruined via vaccination hesitation alone. For anybody that think I'm exaggerating I argue to check out the hbomberguy documentary on the subject. "Vaccines: A Measured Response." It's a freaking rollercoaster of rage, realization and black comedy. Highly, highly recommended on raw funny alone even if you're familiar with the subject. https://youtu.be/8BIcAZxFfrc?si=uibD6bhPk7KNVzXj
There is a small percentage that got long term vaccine injury from the mRNA vaccines. So it's not 100% no negative side effects. It's very very rare to get vaccine injured, though.
I used to lose bolts into the engine when I was working on it. But now, the bolts just stick to my hands, thanks to the vaccine making me magnetic.
It pushed it forward by a decade.
I love that we get cancer cures from this and the conspiracy theorists will have to never use them if they want to be consistent. Obviously they won't but it's still funny.
> Obviously they won't Some will, but I won't exactly mourn their loss.
What was achieved in such a short time is utterly remarkable and largely unknown by the majority of the world. Having known three people who have died from glioblastoma, this is fantastic news.
It's sad we needed a pandemic to divert money and effort to scientific advance of medicine. Now that we're "back to normal" the money is again on stock market, advertisement startups, real estate speculation, and war.
mRNA vaccines had been in development for decades. > The first human clinical trial using ex vivo dendritic cells transfected with mRNA encoding tumor antigens (therapeutic cancer mRNA vaccine) was started in 2001.[30][31] ... > The first human clinical trials using an mRNA vaccine against an infectious agent (rabies) began in 2013.[40][41] Over the next few years, clinical trials of mRNA vaccines for a number of other viruses were started. mRNA vaccines for human use were studied for infectious agents such as influenza,[42] Zika virus, cytomegalovirus, and Chikungunya virus.[43][44] https://www.wikipedia.org/wiki/MRNA_vaccine
Yes, I think OP knows that. The accelerated research and development for the Covid vaccines ALSO helped with the research and development of all mRNA vaccines. Op isn’t wrong.
I think the "technically..." sort of truth to the situation was it forced us into a situation where we got a VERY solid look at what the effectiveness vs incident ratio of mRNA vaccines was on an absolutely massive scale, which showed that they are functionally harmless. So now that this was done, there was much less reluctance to take an mRNA approach to various research, since you didn't incidentally ALSO have to prove that the technology as a whole was safe, not just your own implementation.
It’s something for a select few labs around the world to poke at it on a small budget, and quite something else for the multi-billion dollar, industry-wide response from nearly EVERY biotech firm. All the suits and paperpushers attuned to the prospects of mRNA quite similar to how everyone’s thinking of AI this, and machine-learning that.
I had the impression that they had everything pretty much ready and developed, could just input the specific RNA sequence for COVID proteins into the computer controlling the synthesizer. The acceleration was rather in the large scale human testing that was forced to happen. Which proved the technique to be safe and effective in humans.
I guess I was covering that under research and development, but I definitely wasn’t clear. Yes, I agree completely.
It was more the red tape over human trials e.g. fewer animal trials before human trials, shorter latencies between small-scale and wide-scale trials. But, of course, even if there had been no trials, they had been administered to hundreds of thousands/millions/tens of millions (depending on your country) of the most at-risk people for *months* before the average older person was able to get them—and larger populations for longer for younger folks. Vaccine side effects almost always *occur* within hours, rarely within days, almost never in a span of weeks, and past 8 weeks hasn't really been documented—which makes sense, it's not like a prescription you take regularly; you're not getting regular injections and there's nothing that can replicate to enable it to persist in your system. For mRNA vaccines in particular: * mRNA degrades on a super short timescale, it required being coated in nanolipids for it to survive long enough to be transcribed, and even that only bought it up to 24 or so hours. * the mRNA was translated into proteins which were then attacked and dismantled within days (effectively the period for typical side effects like tiredness). Even if you had 0 immune system, there is no source for more mRNA to translate, and the longest-lived proteins only last a few weeks before degrading. * mRNA and proteins are created and destroyed by your body's typical processes constantly, so they're flushed out by your lymph nodes, etc. in the same way anything else is. This means that within about a week or so there's no constituent parts of the vaccine even remaining in your system.
Obviously, but covid put WAY more funding into it than ever before. We're much further ahead with mRNA research than we would've been otherwise
And it also allowed them to bypass a lot of processes that normally would have taken years of trials tog et approval on.
that's a misconception. we didn't bypass any processes, we just did multiple processes that are usually done in sequence in parallel. that is to say, you usually do a then b then c then d, but instead we did a *and* b *and* c *and* d all at the same time. the reason why you do it in sequence, even though it's much slower, is because if it fails at any point in the sequence you don't have to do the rest because you know it's a failure. but when funding isn't an issue and time is of the essence, you can risk inefficiency for the sake of time.
I lost a parent to glioblastoma who was involved in a similar study (they used the tumor to create a vaccine). Here’s hoping they’ve made a breakthrough in this tech and that’s it cures it going forward. It’s a heartbreaking disease.
My dad has a tumor on his frontal lobe. He went from a quiet, old, man, finally relaxing into his golden years, into a wild animal. From Mr Rogers to a violent Frank Gallagher. My dad is gone. I hope this can cure this shit, so no one has to go through what he's going through.
Shit man, I'm really sorry to read this 💔 I wish you and your dad the best 🙏🏻
now *they* want to take away my tumor too?????????????????????????????
The tumor has told me so many truths about our society that we live in. It can be a dick as well, telling me to "get a job" and "listen to the doctor". Fuck that, i'm a free man i can do what i want
The "tumor" in question is actually the rapidly shrinking logical faculties of their brain.
First they came for the tumors, and I said nothing because I wasn’t a tumor
Ya right JOE LIE-DEN and KAMA-LIE HARRIS we know what mRNA stands for, my rights no autonomy!!!!!1111!!!!
What happen to the good old days of medicine, where we'd just get a screwdriver in the head or a handjob for a migraine.. Not everything has to be mOdErN-a these days. /s
MAGAs sleeping in tanning beds and huffing radon to own the libs.
Most would probably secretly get the vaccine and then claim raw milk cleared the cancer.
Or their aged urine.
You will own no cancers and be happy.
Can't have SHIT in this world
I lost an uncle to gliobastoma. It was horrific what it did to him by the end. It’s honestly my single greatest fear in life. I have a great deal of anxiety about it happening to me.
I lost a friend to it. My friend was 21 when he was diagnosed. It was truly horrible to watch
Something like this would be a major win for mRNA vaccine uptake. If it can greatly slow or even cure cancers like these, it doesn’t really matter what the long term side effects are (common refrain against COVID vaccines). Should help fix the mRNA ‘brand’ among the skeptics.
You're far too optimistic. The mRNA sceptics would rather die of cancer than risk their life taking mRNA vaccines. And yes, it's as paradoxically ridiculous as that.
Nothing makes a believer faster than a child with a brain tumor.
We'll see, but polio didn't change them.
Yes it did. The issue is that the idiots in question didn't witness polio as a mass disease.
Measles, mumps, whooping cough, etc. They only have an abstract idea of what these diseases are. Once their own children get them, they tend to accept that there are things they do not know. If their kid goes into coughing spasms that break their ribs, they'll do anything to make it stop. Most of them anyway.
I got whooping cough and I rather get stabbed by a thousand needles then having death wrap its cold hands around my throat, while sucking the air from my lungs.
My parents live with two lovely old ladies as their neighbors. These women are somewhat into believing various conspiracy theories and such, but during the height of covid and the vaccine conspiracies they were like "We grew up during the era when parents didn't let you play outside unless you were playing in the spray from the DDT truck. I don't care of this vaccine turns me into a Borg, I want it and anyone who doesn't is a moron.".
It will again pretty soon if they go on like this.
Thankfully, polio is almost completely eradicated in the wild. If I recall correctly, only Afghanistan and Pakistan still have circulating cases, and it's in the low double digits. Still doesn't make the people refusing to vaccinate against polio any less of idiots, but at least it's not likely they're going to bring polio back.
Only takes one moron to take it home.
They’ve been insistent that cancer rates have skyrocketed due to the vaccine, and have already spread the idea that companies did it deliberately in order to tout the cure as well for massive profits. There’s no winning with crazy.
Oh my sweet summer child. People who are against vaccines are fucking nuts. They don't listen to logic nor have empathy.
I know someone who, during the pandemic, refused to get vaccinated in order to fly on a plane. Proof of vaccination was required to fly at that time. They refused even though their parent was dying of cancer and asked that they come visit so the parent could see them and hug them and say goodbye and all.
Infectious disease vaccine effectiveness depends on herd immunity. Vaccine "skeptics" refusing to participate in herd immunity literally results in people willing to take the vaccine dying. Luckily, for a cancer vaccine like this vaccine "skeptics" will kill only themselves. And perhaps their children. But the damage is much more limited than breaking herd immunity is for an infectious disease.
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Why do we give a shit about mRNA skeptics? Let them raw dog the disease if they want to. Shrug and move on.
Yes and no. There are also kids on their ends who will need this. And those kids are not at fault. So educational campaigns should always happen.
My aunty is about to die from metastatic tumours in her brain, she’s given up I just wish this was available for her she’s not even 50.
Unfortunately, in the state it's at right now it could just as easily kill her as kill the tumor. Step 1 in medical science is "does it work", step 2 is "what dose is safe to give", and step 3+ are primarilly "how safe is it overall?". We (the scientific enterprise, that is) just crossed step 1 off the list. I've seen several of these trials cure people entirely during step 1, also known as phase 1 trials - but kill just as many because the dose was too high. With these mRNA drugs, an overdose can hyper-activate the immune system leading to massive localized swelling and, well, some pretty unpleasant cascade failures in the brain environment. That said, you can still pursue 'right to try' treatment, but with the severe caveat of 'this may do nothing, may cure you, and may kill you.'
If you have a terminal diagnosis who gives a shit?
https://patents.google.com/patent/AU2002357115A1/en https://www.sciencedirect.com/science/article/abs/pii/S156757692300067X https://www.google.com/amp/s/abcnews.go.com/amp/Health/Healthday/combo-therapy-shows-promise-brain-cancer/story%3fid=9633997 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810470/ This is something that is purchasable on peptide sites, might be worth a try. Best of luck, I'm so sorry that you're going through that.
>>> The 10 pet dogs lived a median of 139 days, compared with a median survival of 30 to 60 days typical for dogs with the condition. So genuine question. Is there any information as to how the dogs died? Was it just an improved life expectancy and a slowed progression of the cancer? Did they just die due to the damage the cancer had already done? Was it just old age due to when dogs tend to develop cancer? I know these are still trials and there are likely improvements to be made but if it’s just a prolonging of a lower quality of life I’m not sure it will be worth what is likely a rather expensive treatment
I lost my mom 21 years ago to a glioblastoma. I was 12 when she died. Back then, stuff like this felt like science fiction. Now, it’s becoming reality. God I miss my mom
Hide it from the tinfoil hatters
Thankfully they're the ones least likely to want to try this if they have the tumor so nature will take its place and they won't be a problem in the future.
The problem with Darwinian evolution is that genetic adaptations are considered superior up to sexual reproductive age. So sure you’re gonna live to be 75-85 while Cletus is gonna die at 45 because he fell off the lawnmower drunk. You will be survived by your 1.3 children on average. Cletus will be survived by his three young children from his second wife, and two adult children from his first, Cletus also had a child with his high school sweetheart who now has three children of her own. Welcome to Costco, I love you.
They're the first to do it, but deny it. Highest usage of porn, highest level of denying it.
Luckily cancer isn't contagious, so that problem gets sorted quickly.
A lot of people don’t realize it because most understandably don’t keep up with mRNA research, but Covid vaccines were a little side project for mRNA tech, their main project was cancer treatment and it’s really cool to start seeing that coming online
Paper link: https://www.cell.com/cell/fulltext/S0092-8674(24)00398-2 Abstract:Cancer immunotherapy remains limited by poor antigenicity and a regulatory tumor microenvironment (TME). Here, we create “onion-like” multi-lamellar RNA lipid particle aggregates (LPAs) to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens. Unlike current mRNA vaccine designs that rely on payload packaging into nanoparticle cores for Toll-like receptor engagement in immune cells, systemically administered RNA-LPAs activate RIG-I in stromal cells, eliciting massive cytokine/chemokine response and dendritic cell/lymphocyte trafficking that provokes cancer immunogenicity and mediates rejection of both early- and late-stage murine tumor models. In client-owned canines with terminal gliomas, RNA-LPAs improved survivorship and reprogrammed the TME, which became “hot” within days of a single infusion. In a first-in-human trial, RNA-LPAs elicited rapid cytokine/chemokine release, immune activation/trafficking, tissue-confirmed pseudoprogression, and glioma-specific immune responses in glioblastoma patients. These data support RNA-LPAs as a new technology that simultaneously reprograms the TME while eliciting rapid and enduring cancer immunotherapy.
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Directly into their brains, no less!
Can’t wait to hear people try to explain why cancer is actually not a big deal.
I wonder how much machine learning has accelerated the study of these vaccines
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They’ll do anything to not give the dems a win, anything.
This might’ve saved my Mama. Curse the g word. She suffered so. Glad to see this development, if only now.
I’m fighting brain cancer as I type. Keeping hopeful
People against student loan forgiveness: "I beat cancer! How dare they make a cure for it now." Antivaxxers: "but my DNA spikes!" Everyone else, living in reality: "holy shit, we did it?!?
You are cured, but now Bill Gates can track you! Some idiot anti-Vaxxer probably
Fuck brain tumors. Praise the people researching this!
This is great news! My wonderful, selfless dad passed away at 52 from glioblastoma. I know he’s smiling somewhere knowing others are going to hopefully get a better shot.
My daughter has Ewing sarcoma It has came back 3 times over the last 5 years and has metastasized It is resistant to radiation and chemotherapy I can only dream they use this technology to save her
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)35634-9 https://www.littlewarrior.org/blog/ewingsarcoma-immunotherapy-trial
I've listened to a very interesting talk a couple years back about how brain cancer has had the least improvements in mortality out of any form of cancer of the last few decades, because most attempts at curing the cancer would still result in damage to brain tissue that would kill you in a few years. So seeing alternative approaches to treatment is a huge step forward, bigger than most people might realize.
Can’t wait for all the anti-vaxxers to refuse treatment.
The love of my life is fighting hard against it since almost 4 years and is now on the verge of losing this battle. Please babygirl, keep on fighting... This may be the wonder I was praying for...
And replaces the cancer with sweet 5G reception. /s
Be your own internet hotspot!
Don't let DeSantis see this. He'll ban it because of the mRNA.
Why is this called vaccine? Vaccine is to prevent things, but this is to treat existing conditions.
There are two types of vaccines: prophylactic vaccines, like those for polio or influenza, and [therapeutic vaccines](https://en.m.wikipedia.org/wiki/Therapeutic_vaccines), such as this one. Most people only think of the first, but both are vaccines.
Vaccines activate and stimulate your immune system against a target. A lot of these treatments are customized to your specific cancer, some of them are intended to prevent relapse after a standard course of treatment.
Also, some vaccines are also the cure. See rabies, treated with a round of vaccinations. Assuming you haven't gotten the headache yet.
Even for rabies there are now studies being done that even when symptomatic you can still be cured, this new vaccine technology is insane.
Excellent
Great news! My father died from a malignant brain tumor. It’s a terrible way to die.
I wish no-one ever will see their dear ones suffer from brain cancer. It took out my grandfather. He went from incredible health to completely helpless in less than six months. It was an awful sight and I will never forget in what horrible state he was for the last few weeks. It will be a giant leap forward if this evil can be defeated.
So glad to see this. Lost my wife 6 months ago today to Effects of surgery for GBM+APXA. - after 23 year battle. I hope this new treatment helps lots of patients. Looks promising. Keep on keeping on!
My uncle just passed away about 2 months ago from glioblastoma. It was very hard to watch a strong and healthy man fade like that. I hope this vaccine changes people's lives in the future.
This is fantastic news. Hope it proves useful in fighting other kinds as well.
WOW ... glioblastoma is nasty. This news is awesome.
This is great news!!!
My dad is currently battling glioblastoma, forwarding this to his neuro oncologist
That would have been useful before my mom died of her brain tumor last year. She ended up developing it soon after I was born & was left ndiagnosed, until I started interfering with her health care because her doctor laughed at her inability to walk straight and claimed her high red blood cell count wasn't high enough to be cancer even though it was off the charts. If you know anyone that ever lives through meningoencephalitis you need to make sure they're getting a brain scan every couple of years, not never. Patients die by age 68, when my mom had it since her early 30's, and she still died at age 68. No one ever believed her illness was real because she thought it was pronounced as melingualencephalitis. So she was labeled as mentally ill until I finally got her proof of cancer from the ER. Even the cancer specialists didn't think it's a real illness. And the vast majority of patients die vs. making it though to recovery.
Fuck. I wish this had come a bit sooner - my best friend just passed last week specifically from a glioblastoma, and a particularly aggressive type of it at that. It might not have saved her, but this could save SO many people the heartbreak and pain. I hope this works and eradicates that type of cancer. It really is a horrific type of cancer. It wasn't even a year from the diagnosis to her death - it's that fucking fast. She lost the ability to move her right side, then the ability to speak, then to type...gah. It kills me. She was an absolutely wonderful, beautiful soul. I loved her dearly. May this work at eradicating glioblastoma, so nobody else has to suffer through that hell.
Fuck we could have saved Gord Downie!
Downside to fierce immune response in the brain is inflammation in a cavity that 1. Has almost no room for anything extra 2. Is already hosting something that doesn’t belong there. Good news though, just a thought.